Uptake of 2′-amino-2′-deoxyguanosine by Escherichia coli and its competition by guanosine

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  • Uptake of 2'-amino-2'-deoxyguanosine by Escherichia coli and its competition by guanosine.
  • Uptake of 2 amino 2 deoxyguanosine by E

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The antibacterial activity of a new nucleoside antibiotic, 2'-amino-2'-deoxyguanosine (2AG), is reversed by guanosine and other purine nucleosides. 2AG is apparently taken up by E. coliby a mechanism different from that of guanosine; guanosine inhibits this uptake non-competitively. Insensitive E. colistrains and the resistant mutant obtained from the sensitive strain also took up 2AG.

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