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- UEHARA YOSHIMASA
- Institute of Microbial Chemistry
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- HORI MAKOTO
- Institute of Microbial Chemistry
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- KONDO SHINICHI
- Institute of Microbial Chemistry
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- HAMADA MASA
- Institute of Microbial Chemistry
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- UMEZAWA HAMAO
- Institute of Microbial Chemistry
Bibliographic Information
- Other Title
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- Structure activity relationships among
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Description
Various negamycin analogs were examined for (1) miscoding activity and (2) inhibition of the termination of protein synthesis. Since properties (1) and (2) do not correlate for the investigated compounds they may depend on different structural features of negamycin analogs. The results of biochemical and antimicrobial studies indicate that (a) the natural configuration of the carbon atom carrying the β-amino group is essential, (b) the δ-hydroxyl group is unnecessary, and (c) the acylation of the ε-amino group causes loss of activity.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 29 (9), 937-943, 1976
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390282679131646208
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- NII Article ID
- 130003499257
- 40005313894
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- NII Book ID
- AA0069330X
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- COI
- 1:CAS:528:DyaE28XlslahsLo%3D
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- ISSN
- 18811469
- 00218820
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- NDL BIB ID
- 1726702
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- PubMed
- 791912
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed