FLUOROMETRIC EVIDENCE FOR THE BINDING OF CHOLESTEROL TO THE FILIPIN COMPLEX
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- SCHROEDER F.
- Department of Biochemistry, Michigan State University
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- HOLLAND J. F.
- Department of Biochemistry, Michigan State University
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- BIEBER L. L.
- Department of Biochemistry, Michigan State University
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The data show that the filipin complex in water has a characteristic fluorescence spectrum with a broad emission maxima at 497nm. Addition of cholesterol to the aqueous solution decreases the absorbance, the corrected fluorescence, and the partial quantum efficiency. The reduction in partial quantum efficiency, which is independent of the concentration of filipin, is definitive evidence that the filipin complex interacts with sterols in aqueous solution. The data indicate that changes in fluorescence may be a sensitive tool for monitoring the interaction of filipins with sterols.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 24 (12), 846-849, 1971
公益財団法人 日本感染症医薬品協会
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- CRID
- 1390282679131919488
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- NII論文ID
- 130003498352
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- NII書誌ID
- AA0069330X
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 8510278
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- PubMed
- 5140531
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- 本文言語コード
- en
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- データソース種別
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