Piperacillin (T-1220), a new semisynthetic penicillin: in vitro antimicrobial activity comparison with carbenicillin, ticarcillin, ampicillin, cephalothin, cefamandole and cefoxitin.

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  • JONES R. N.
    Clinical Microbiology Laboratory, Kaiser Foundation Hospital Laboratories
  • THORNSBERRY C.
    Antimicrobic Investigation Section, Center for Disease Control
  • BARRY A. L.
    Clinical Microbiology Laboratories, University of California (Davis) Sacramento Medical Center
  • FUCHS P. C.
    Department of Pathology, St. Vincent Hospital and Medical Center
  • GAVAN T. L.
    Department of Microbiology, The Cleveland Clinic
  • GERLACH E. H.
    Microbiology Laboratory, St. Francis Hospital

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タイトル別名
  • Piperacillin T 1220 a New Semisynthetic

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Piperacillin (T-1220) is a new semisynthetic penicillin with an unusually broad spectrum of antimicrobial activity. In vitro comparisons of this drug with 6 other beta-lactam antimicrobics (ticarcillin, carbenicillin, ampicillin, cephalothin, cefamandole and cefoxitin) were conducted. These included minimal inhibitory concentrations (MIC) against 394 bacterial isolates, the minimal lethal concentrations (MLC) against 79 of those, as well as the effect of inoculum size on the MIC and MLC of the drugs. Piperacillin had significantly greater activity than did the other penicillins against Pseudomonas species and Klebsiella pneumoniae. Against P. aeruginosa piperacillin was 8- and 16-fold more active than ticarcillin and carbenicillin, respectively. The MLC of piperacillin rarely differed from the MIC by more than one log2 dilutions except against P. aeruginosa in which the MLC was 4-fold greater or more than the MIC of 45% of isolates tested. Ticarcillin, carbenicillin and cefoxitin showed minimal inoculum size effects. Cefamandole results showed the greatest inoculum size variation with 55% and 37% of isolates showing an 8-fold increase in MIC and MLC respectively by increasing inoculum from 105 to 107 CFU/ml. Piperacillin was intermediately effected having 25% of strains >8-fold increase in MIC.

収録刊行物

  • The Journal of Antibiotics

    The Journal of Antibiotics 30 (12), 1107-1114, 1977

    公益財団法人 日本感染症医薬品協会

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