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- GROUPE VINCENT
- National Institutes of Health, National Cancer Institute, DCCR
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- DONOVICK RICHARD
- American Type Culture Collection
Bibliographic Information
- Other Title
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- Experiences in the Search for Anti Infl
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Abstract
Whole shaken cultures of 20 random, unidentified actinomycetes were extracted with n-butanol at pH 4.5, 7.0, and 8.5, respectively. Residues of butanol-extractable materials (BXM) were reconstituted (100×) in buffers and freeze-dried. BXM were surprisingly well tolerated in animals and were screened against influenza A viral pneumonia in mice. One culture yielded BXM-80 which suppressed both chemical (LPS) and viral (NDV) pneumonia in mice as well as inhibited rat foot pad edema induced by carrageenin. Aspirin, Butazolidin, hydrocortisone, indomethacin, and prednisolone, which are known to inhibit carrageenin-induced rat foot pad edema were tested against chemical (LPS) and viral (NDV) pneumonia in mice. Only hydrocortisone and prednisolone suppressed LPS pneumonia. All of these 5 compounds failed to inhibit NDV pneumonia. Microbial products are suggested as a source for new and unique anti-inflammatory agents.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 30 (12), 1080-1086, 1977
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390282679131964032
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- NII Article ID
- 130003499322
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- NII Book ID
- AA0069330X
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- COI
- 1:CAS:528:DyaE1cXhtlSrsLo%3D
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- ISSN
- 18811469
- 00218820
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- NDL BIB ID
- 1916982
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- PubMed
- 413820
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed