Synthesis of a 125I-labelled derivative of the antibiotic griseofulvin.

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  • LECOINTE P.
    Laboratoire de Pharmacologie et de Toxicologie Fondamentales
  • WRIGHT M.
    Laboratoire de Pharmacologie et de Toxicologie Fondamentales
  • DEDIEU A.
    Laboratoire de Pharmacologie et de Toxicologie Fondamentales

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  • Synthesis of a 125I labelled derivative

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A derivative of griseofulvin has been synthesised, in which the 2'-O-methyl group is replaced by a 2'-(2-iodoethoxy), 125I-labelled group. This derivative is at least as potent as griseofulvin itself, when assayed for inhibition of growth on the Myxomycete Physarum polycephalum.

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