Affinity for a Malignant Tumor and Organs of the Elements in Group V of the Periodic Table

ANDO Atsushi, HISADA Kin-ichi

doi:10.3769/radioisotopes.22.6_286

In order to investigate the tumor affinity radioisotopes, vanadium (V-48), niobium (Nb-95), tantalum (Ta-182), arsenic (As-74) and antimony (Sb-124) —the elements of group V in the periodic table—were examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma. Six preparations, ⁴⁸VO₂Cl, ⁹⁵Nb-oxalate, ¹⁸²Ta-oxalate, Na₂H⁷⁴AsO₄ (Na₂HAsO₄0.008μg), Na₂HAsO₄ (Na₂HAsO₄1 mg) and¹²⁴Sb-chloride were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations. The radioactivities of the tumor, blood, muscle, liver, kidney and spleen were measured by a well-type scintillation counter, and retention values in every tissue including the tumor were calculated (in percent of administered dose per g-tissue weight) .<BR>⁹⁵Nb-oxalate had considerably strong affinity for the malignant tumor.⁴⁸VO₂Cl, ¹⁸²Ta-oxalate, Na₂H⁷⁴AsO₄and¹²⁴Sb-chloride did not have any affinity for the malignant tumor. But⁴⁸VO₂Cl had fairly strong affinity for the kidney, Na₂H⁷⁴AsO₄had very strong affinity for blood-corpuscles and strong affinity for the spleen.¹⁸²Ta-oxalate and¹²⁴Sb-chloride did not have any affinity for the organs and¹⁸²Ta-oxalate was slowly excreted and¹²⁴Sb-chloride was rapidly excreted in urine.

Affinity for a Malignant Tumor and Organs of the Elements in Group V of the Periodic Table

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