書誌事項
- タイトル別名
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- On Renal Excretion of Sodium 4-iodo-5-methylpyrazole-3-carboxylate-<SUP>131</SUP>I
- Sodium 4 iodo 5 methylpyrazole 3 carbox
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Sodium 4-iodo-5-methylpyrazole-3-carboxylate-131I (IMPC-131I) was synthesized by isotope exchange with Na 131I in the molten state to evaluate its potential usefulness as a renal function and/or imaging agent. Tissue distribution and clearance characteristics of IMPC-131I are described.<BR>Tissue distribution experiments in rats indicated a very high renal concentration of radioactivity following intravenous administration. At 5 min the kidney took up 27.8% of the injected dose (16.1% dose per gram) and the total activity in the kidney still accounted for 9.8% of the injected dose at 30 min, with only 1.2% localizing in the liver. The ratios for kidney-to-liver in the concentration of IMPC-131I were always higher than those of hippuran-131I throughout the period of the experiment. Within 24 hr, 78.6% of the injected dose were excreted in the urine. The autoradiographic and the scannographic studies were also performed. The present results suggest that IMPC-131I has potential as a new agent for both function and imaging studies of the kidney.
収録刊行物
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- RADIOISOTOPES
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RADIOISOTOPES 28 (5), 300-305, 1979
公益社団法人 日本アイソトープ協会
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詳細情報 詳細情報について
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- CRID
- 1390282679133013248
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- NII論文ID
- 130004381118
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- NII書誌ID
- AN00351589
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- ISSN
- 18844111
- 00338303
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- NDL書誌ID
- 2050914
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- PubMed
- 472379
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可