Importance of a 99Mo/99mTc Generator and a Perspective of Nuclear Medicine in the Face of the Difficult Situation of Supply Shortage of 99mTc from the Viewpoint of a Nuclear Medicine Specialist

KOSUDA Shigeru

doi:10.3769/radioisotopes.59.329

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テクネチウム－９９ｍ供給不足事態における｀９９´Ｍｏ／｀９９ｍ´Ｔｃジェネレータの重要性と核医学展望ー核医学専門医の立場から
テクネチウム-99m供給不足事態における99Mo/99mTcジェネレータの重要性と核医学展望--核医学専門医の立場から
テクネチウム 99m キョウキュウブソクジタイニオケル 99Mo 99mTc ジェネレータノジュウヨウセイトカクイガクテンボウカクイガクセンモンイノタチバカラ

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Description

In this review a list of commercially available ^99mTc-labeled radiopharmaceuticals was presented, and the significance to use them clinically was described in the face of this difficult situation due to the ^99mTc shortage. The supply history and the chronological change in the sales of ⁹⁹Mo/^99mTc generators in Japan were also described. I emphasize the importance of a nationwide spread of dedicated SPECT/CT equipments, which provide not only a simultaneous acquisition of dual tracers, but also information on both function and morphology. The present issues to address this difficult situation were discussed, referring to the summary of the OECD/NEA workshop held in Paris and the press conference at the 56^th SNM annual meeting held in Toronto. The results of a questionnaire survey conducted in Saitama prefecture suggested the procedures, such as a domestic self-supply of ⁹⁹Mo, to resolve the issues related to the shortage. In addition, the ongoing JMTR project regarding self-supply of ⁹⁹Mo was described. Based on a reliable supply of ^99mTc, the following suggestions to develop nuclear medicine were presented from the viewpoint of a nuclear medicine specialist; development of a brand-new SPECT/CT equipment using semi-conductor, clinical application of new tracers, and reassessment of the existing SPECT studies.

Journal

RADIOISOTOPES

RADIOISOTOPES 59 (5), 329-339, 2010

Japan Radioisotope Association

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