Affinity for a Malignant Tumor and Organs at the Elements in Group VII of the Periodic Table

ANDO Atsushi, HISADA Kinichi, ANDO Itsuko, TERADA Kikuo

doi:10.3769/radioisotopes.25.11_706

In order to investigate the tumor affinity radioisotopes, manganese (⁵⁴Mn), technetium (^99mTc), rhenium (¹⁸⁶Re), bromine (⁸²Br) and iodine (¹³¹I) -the elements of group VII in the periodic table-were examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma. Five preparations, manganese chloride (⁵⁴MnCl₂), sodium pertechnetate (Na^99mTcO₄), sodium perrhenate (Na¹⁸⁶ReO₄), ammonium bromide (NH₄⁸²Br) and sodium iodide (Na¹³¹I) were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations but sodium pertechnetate, 1 hour, 3 hours and 24 hours in sodium pertechnetate. The radioactivities of the tumor, blood, muscle, liver, kidney spleen and others were measured by a well-type scintillation counter, and retention values (in every tissue including the tumor) were calculated in percent of administered dose per g-tissue weight.<BR>All of five preparations did not have any affinity for malignant tumor. ⁵⁴MnCl₂ was excreted very slowly out of the body and had some affinity for the pancreas. As Na^99mTcO₄ and Na¹⁸⁶ReO₄ was rapidly excreted into the urine, retention values of these two compounds in the organs was very small. NH₄⁸²Br was excreted very slowly out of the body. In Na¹³¹I, a large amount of iodine-¹³¹I was accumulated into the thyroid, but retention values of Na¹³¹I in other organs was very small.

Affinity for a Malignant Tumor and Organs at the Elements in Group VII of the Periodic Table

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