元素の周期律表での位置と腎臓親和性との関連に関する考察

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  • Relations between Location of Elements in Periodic Table and Affinity for the Kidneys
  • ゲンソ ノ シュウキリツヒョウ デ ノ イチ ト ジンゾウ シンワセイ ト ノ

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The distribution of many inorganic compounds in rats was investigated in order to evaluate kidney affinity of inorganic compounds. In these experiments, 30%, 10-20% and 4-10% of administered dose was localized in the kidneys in 203Hg-acetate and 203Bi-acetate, in H198AuCl4, 103PdCl2, 201TlCl, 210Pd (NO3) 2 and H2127mTeO3, and in Na251CrO4, 54MnCl2, 114mInCl3 and 7BeC12, respectively. Some bipositive ions and anions was hardly taken up into the kidneys. And in many hard acids accordings to classification of Lewis acids, the uptake rate into the kidneys was usually small.<BR>On the other hand, Hg, Au and Bi, which have strong binding power to the protein, showed high uptake rate in the kidneys. As Hg++, Au+ and Bi+++ was soft acids according to classification of Lewis acids, it was thought that these elements would bind strongly to soft base (RSH, RS-) present in the kidney.

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