Measurement of Iodine-Derived Contamination in L-[<sup>11</sup>C]Methionine Injection

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  • Komatsu Yukiko
    Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University
  • Nishijima Ken-ichi
    Central Institute of Isotope Science, Hokkaido University Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University
  • Oomagari Shigeo
    SHI Accelerator Service Co., Ltd.
  • Kanai Yasukazu
    Department of Molecular Imaging in Medicine, Graduate School of Medicine, Osaka University
  • Naka Sadahiro
    Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University
  • Higashikawa Kei
    Central Institute of Isotope Science, Hokkaido University Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University
  • Ebita Yoko
    Central Institute of Isotope Science, Hokkaido University
  • Shiga Tohru
    Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University
  • Hatazawa Jun
    Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University
  • Tamaki Nagara
    Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University
  • Kuge Yuji
    Central Institute of Isotope Science, Hokkaido University Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University

Bibliographic Information

Other Title
  • L-［<sup>11</sup>C］メチオニン注射液中に混入するヨウ素由来不純物の測定法に関する検討
  • Measurement of Iodine-Derived Contamination in L-[¹¹C]Methionine Injection

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Abstract

<p>Measurement methods for iodine-derived contamination in L-[11C]methionine injection were evaluated. L-[11C]Methionine injection and samples from the mock synthesis routes where iodine vapor was introduced with or without passing precolumns of sodium hydroxide-coated silica (Ascarite columns) were used. The contents of total iodine, iodide ion, and I2 were determined by ICP-MS, HPLC-UV detection, and N,N-diethyl-1,4 phenylenediamine method, respectively. Total iodine contents measured by ICP-MS indicated the potentials of Ascarite columns for removing I2 . The iodine-derived contamination existed as iodide ion in the L-[11C]methionine injections. Accordingly, measurement of iodide ion by HPLC offers a rapid and useful means of controlling the manufacturing processes of L-[11C]methionine injection.</p>

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 67 (3), 75-83, 2018

    Japan Radioisotope Association

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