ChemInform Abstract: Total Syntheses of Novel Cytocidal β‐Carboline Alkaloids, Oxopropalines D and G.
書誌事項
- タイトル別名
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- Total Syntheses of Novel Cytocidal .BETA.-Carboline Alkaloids, Oxopropalines D and G.
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説明
A new type of β-carboline nucleus, N-methoxymethyl-4-methyl-β-carboline (4) was synthesized by thermal electrocyclic reaction of a 1-azahexatriene system, involving the indole 2, 3-bond. The key compound N-methoxymethyl-1-methoxycarbonyl-4-methyl-β-carboline (2) was then prepared in a four-step sequence. The total synthesis of oxopropaline G (1e) was achieved from this key compound in four steps. Furthermore, the enantioselective total syntheses of (+)-oxopropaline D (1c) and its enantiomer were also achieved by application of the Sharpless oxidation-procedure in nine steps from 2.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 48 (1), 108-113, 2000
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679134927104
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- NII論文ID
- 130003947967
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- COI
- 1:CAS:528:DC%2BD3cXmvFahsQ%3D%3D
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- ISSN
- 13475223
- 15222667
- 00092363
- 09317597
- http://id.crossref.org/issn/00092363
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- PubMed
- 10705485
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- 本文言語コード
- en
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- 資料種別
- journal article
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- JaLC
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- PubMed
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