Acid-promoted Cyclization of Tetronic Acid to Alkene; Chemical Transformation of (-)-Ircinianin to (+)-Wistarin.
Bibliographic Information
- Other Title
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- Acid-promoted Cyclization of Tetronic A
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Abstract
The perchloric acid-promoted transformation of (-)-ircinianin (1) to (+)-wistarin (2) is described. The reaction of 1 with perchloric acid in acetonitrile gave 2 in 35% yield along with a positional isomer 4 in 35% yield. The structure of 4 was determined by two dimensional (2D) NMR studies. On the other hand, the reaction of 2-methyl-4-prenyltetronic acid (6), as a model compound for the above transformation, gave the cyclized product 8 corresponding to 2 in 58% yield and the keto-lactone 9 in 22% yield under the same conditions.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 46 (7), 1090-1093, 1998
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679135934976
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- NII Article ID
- 130003773826
- 110003616984
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 4538348
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed