Synthesis of (.+-.)-(4a.ALPHA.,6a,7.ALPHA.,7a.ALPHA.)-Hexahydro-6-hydroxy-7- methylcyclopenta(c)pyran-3(1H)-one, a Structure Common to Abelialactone, Aglykon A1, and Isoboonein.
Description
Synthesis of (±)-(4aα, 6α, 7α, 7aα)-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-3(1H)-one [(±)-1] has been achieved through an 8-step route starting from 6, 7-dihydrocyclopenta-1, 3-dioxin-5(4H)-one (4). The identities of synthetic (±)-1 with abelialactone, Aglykon A1, and isoboonein permitted the unequivocal assignment of this common structure and the relative stereochemistry to these cyclopentano-monoterpene lactones.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 44 (3), 525-529, 1996
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679136596352
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- NII Article ID
- 130003773390
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- ISSN
- 13475223
- 00092363
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed