A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection.

DOI Web Site Web Site PubMed 1 Citations 26 References

Bibliographic Information

Other Title
  • Reductive Acidolysis Final Deprotection

Search this article

Description

A reductive acidolysis final deprotection strategy in solid phase peptide synthesis was developed using a new safety-catch type of semi-permanent protecting groups and new linkers which were derived from 4-methylsulfinylbenzyl protection. This new strategy was based on a two-dimensional protection scheme employing acid-labile temporary and acid-stable but reductive acidolysis-cleavable semi-permanent protecting groups. By using this strategy, we successfully synthesized four model peptides, of which two contained C-terminal amide.

Journal

Citations (1)*help

See more

References(26)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top