Studies on Sialic Acids. Part XXVIII. Synthesis of Disaccharide Nucleoside Derivatives of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN).

DOI Web Site 被引用文献3件

抄録

The reaction of benzyl 4, 5, 7, 8, 9-penta-O-acetyl-2-bromo- or -chloro-2, 3-dideoxy-D-glycero-β-D-galacto-2-nonulopyranosonate (2, 3) with uridine, 5-fluorouridine, and cytidine under Koenigs-Knorr reaction conditions gave the corresponding (2→5) linked disaccharide uncleoside derivatives, in yields of 32-47%. A similar reaction of 3 with inosine gave the (2→N1) linked derivative. These uncleoside analogues were converted into the final target compounds.The configuration at the anomeric position of these compounds was elucidated by means of proton and carbon unclear magnetic resonance (1H-, 13C-NMR)analysis, and consideration of the rate of hydrolysis of the (2→5) glycosidic linkage.

収録刊行物

被引用文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ