Prostanoids and Related Compounds. VII. Synthesis and Inhibitory Activity of 1-Isoindolinone Derivatives Possessing Inhibitory Activity against Thromboxane A2 Analog (U-46619)-Induced Vasoconstriction.

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We have synthesized a series of novel 1-isoindolinone derivatives, which inhibited the contraction of pig coronary artery induced by U-46619, a thromboxane A2 analog.

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