A Practical Procedure for the Synthesis of Esonarimod, (R,S)-2-Acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic Acid, an Antirheumatic Agent. (Part 1).

DOI Web Site Web Site PubMed 20 References

Bibliographic Information

Other Title
  • Practical Procedure for the Synthesis of Esonarimod R S 2 Acetylthiomethyl 4 4 methylphenyl 4 oxobutanoic Acid an Antirheumatic Agent Part 1

Search this article

Abstract

An efficient and practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (1), a new antirheumatic drug, has been developed. The intermediate, 2-methylene-4-(4-methylphenyl)-4-oxobutanoic acid (2), was prepared by Friedel–Crafts acylation of toluene with itaconic anhydride (3) in the presence of aluminum trichloride and nitrobenzene in 63% yield without silica gel column purification. Compound 1 was prepared by Michael addition of 2 with thioacetic acid (4) in 74% yield. Overall, 1 was obtained in 47% yield from 3. The structures and synthetic mechanisms of by-products (five compounds) of 2 were also clarified.

Journal

References(20)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top