Identification of steroidal compounds as acetates in a lysate of "Depressor-I", an antihypertensive phospholipid occurring in acetone-soluble fraction of bovine brain.
説明
The alkaline hydrolysate of "Depressor-I", an antihypertensive phospholipid occurring in the acetone-soluble fraction of bovine brain, was [3H] acetylated and applied to an alumina column. Various [3H] acetylated compounds were eluted. Among the major fractions, the eluates with hexane and hexane-benzene (9 : 1, 7 : 3 and 5 : 5, v/v) mixtures contained labile compounds which decomposed on standing for one month. Gas chromatography-mass spectrometry was carried out with the corresponding sample obtained in a "cold"experiment, and diosgenin acetate, a sapogenin, was detected besides cholesteryl acetate. A new class of phospholipid containing steroidal components is proposed.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 33 (4), 1334-1341, 1985
公益社団法人 日本薬学会