Diastereoselective Solid-Phase Radical Addition to Oxime Ether Anchored to Polymer Support

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Stereocontrol in radical reactions of oxime ether anchored to polymer support was studied. Highly diastereoselective solid-phase radical reaction was achieved by using triethylborane and diethylzinc as a radical initiator at low reaction temperature, providing a novel method for the synthesis of the α-amino acid derivatives with excellent diastereoselectivities.

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