Preparation of New Nitrogen-Bridged Heterocycles. 51. Syntheses and Structures of Compounds Having Two Indolizine Nuclei in a Molecule.
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- KAKEHI Akikazu
- Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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- ITO Suketaka
- Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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- SUGA Hiroyuki
- Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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- SAKURAI Shinji
- Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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- KOBAYASHI Tomoshige
- Faculty of Science, Shinshu University
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Abstract
New compounds having two indolizine nuclei in a molecule were prepared in low to moderate yields from the reactions of potassium 2-indolizinethiolates with 1,ω-dihalides such as 1,2-diiodoethane, 1,3-dibromopropane, 1,4-dibromobutane, α,α'-dichloro-o-xylene, and α,α'-dichloro-p-xylene. Most of the products had the conformation in which the two indolizine rings in the molecule are as remote as possible, but only 1,2-bis[[(2-indolizinyl)thio]methyl]benzene derivatives, prepared from potassium 2-indolizinethiolates and α,α'-dichloro-o-xylene, showed a weak attractive interaction between the two indolizine nuclei in the X-ray analysis and the nuclear Overhauser and exchange spectroscopy (NOESY) spectrum.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 49 (11), 1401-1405, 2001
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679139326976
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- NII Article ID
- 110003615804
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXotFagsbk%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 5954108
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- PubMed
- 11724229
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed