Design and synthesis of N-(N-((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-N-(indan-2-yl)glycine (CV-3317), a new, potent angiotensin converting enzyme inhibitor.

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  • Design and synthesis of N-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyI]-N-(indan-2-yl)g!ycine (CV-3317), a new potent angiotensin converting enzyme inhibitor

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A new angiotensin converting enzyme (ACE) inhibitor, N-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-N-(indan-2-yl)glycine (9a), was found as a result of extensive studies on the structural requisites for the C-terminal amino acid moiety in ACE inhibitors. The synthesis and the determination of the absolute configuration of 9a are described.

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