New Insulinomimetic Zinc(II) Complexes of α-Amino Acidsand Their Derivatives with Zn(N2O2) Coordination Mode

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  • YOSHIKAWA Yutaka
    Department of Chemistry, Graduate School of Science, Osaka City University
  • UEDA Eriko
    Department of Chemistry, Graduate School of Science, Osaka City University
  • SUZUKI Yuka
    Department of Materials Science and Engineering, Teikyo University
  • YANAGIHARA Naohisa
    Department of Materials Science and Engineering, Teikyo University
  • SAKURAI Hiromu
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
  • KOJIMA Yoshitane
    Department of Chemistry, Graduate School of Science, Osaka City University

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タイトル別名
  • New Insulinomimetic Zinc(II) Complexes of .ALPHA.-Amino Acids and Their Derivatives with Zn(N2O2) Coordination Mode.
  • New Insulinomimetic Zinc 2 Complexes of アルファ Amino Acidsand Their Derivatives with Zn N2O2 Coordination Mode

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Zinc(II) complexes of α-amino acids and their derivatives with a Zn(N2O2) coordination mode were found to have in vitro insulinomimetic activity as estimated with the inhibition of free fatty acid release in isolated rat adipocytes treated with epinephrine. It was revealed that the insulinomimetic activities of zinc(II) complexes with over-all stability constants (log β) less than 10.5 are higher than those of ZnSO4 and VOSO4. The high blood glucose level of KK-Ay mice with type 2 diabetes mellitus was lowered by daily intraperitoneal injections of a zinc(II) complex, cis-[Zn(L-Thr)2(H2O)2], for 14d. The improvement of diabetes mellitus was confirmed with the oral glucose tolerance test.

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