Electron Spin Resonance Studies of Dipalmitoylphosphatidylcholine Liposomes Containing Soybean-Derived Sterylglucoside.
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The effects of soybean-derived sterylglucoside (SG) on the fluidity of liposomal membrane composed of dipalmitoylphosphatidylcholine (DPPC) were investigated compared with those of soybean-derived sterol (SS) and cholesterol (Ch) using an electron spin resonance spectrometer. Three kinds of liposomes were prepared in the molar ratio of DPPC/X=7/4, where X is SS, Ch or SG. The fluidity close to the polar head groups increased with an increase of temperature in the DPPC membrane containing SS, Ch and SG in the range 35 to 45°C. Those near the hydrophobic end changed with an increase in temperature in liposomes containing SS, Ch and SG, which had a fluidizing effect on the DPPC membrane below the transition temperature (Tm, 41.9°C) and a condensing effect over the Tm. The fluidizing effects of these compounds around 37°C near the polar head group and the hydrophobic end increased in the following order : Ch<SG≤SS and SS<Ch<SG, respectively. SG increased the fluidity of liposomal membrane dramatically above the Tm (35.4°C). These results suggest that the high fluidity close to the hydrophobic end of the liposomal membranes around 37°C, the decrease of Tm, and the sigmoidal nature of fluidity vs. temperature are important factors in the effectiveness of liposomes containing SG as a carrier of drugs.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 48 (5), 610-613, 2000
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679139964544
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- NII論文ID
- 130003774076
- 110003635519
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3cXjtFWhtrk%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 5364800
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- PubMed
- 10823694
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
