Spirocyclopropane compounds. II. Synthesis and biological activities of spiro(cyclopropane-1,2'-(2H)indol)-3'(1'H)-ones.

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Spiro [cyclopropane-1, 2'-[2H] indol]-3'(1'H)-ones with various substituents on the benzene ring and at the 1'-position were synthesized. Investigation of their biological activities revealed that significant anti-inflammatory and analgesic activities were exhibited by some compounds of this series. Their structure-activity relationships are discussed.

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