Partial Hydrolysis of Soyasaponin 1 and the Hepatoprotective Effects of the Hydrolytic Products.Study of the Structure-Hepatoprotective Relationship of Soyasapogenol B Analogs

DOI Web Site Web Site PubMed 被引用文献11件 参考文献30件 オープンアクセス

書誌事項

タイトル別名
  • Partial Hydrolysis of Soyasaponin I and the Hepatoprotective Effects of the Hydrolytic Products. Studies on the Hepatoprotective Drugs. Part IV. (Studies on the Constituents of the Leguminous Plants. Part LVII.) Study of the Structure-Hepatoprotective Relationship of Soyasapogenol B Analogs.
  • Partial Hydrolysis of Soyasaponin 1 and
  • Partial hydrolysis of soyasaponin I and the hepatoprotective effects of the hydrolytic products. Study of the structure-hepatoprotective relationship of soyasapogenol B analogs

この論文をさがす

説明

As a part of our studies of hepatoprotective drugs, we prepared some soyasapogenol B analogs from soyasaponin I. We examined the hepatoprotective effects of these analogs, using immunologically-induced liver injury, in primary cultured rat hepatocytes. Soyasaponin III and soyasapogenol B monoglucuronide were more effective than soyasaponin I. Both compounds were significantly effective even at 30μM. The action of soyasapogenol B was almost equal to that of soyasaponin I, although glucuronic acid did not show any activity even at the highest dose (500μM). When the two compounds were mixed, the hepatoprotective action did not change, compared with soyasapogenol B. Therefore, we concluded that the linkage between glucuronic acid and soyasapogenol B could enhance the hepatoprotective activity.

収録刊行物

被引用文献 (11)*注記

もっと見る

参考文献 (30)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ