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Partial Hydrolysis of Soyasaponin I and the Hepatoprotective Effects of the Hydrolytic Products. Studies on the Hepatoprotective Drugs. Part IV. (Studies on the Constituents of the Leguminous Plants. Part LVII.) Study of the Structure-Hepatoprotective Relationship of Soyasapogenol B Analogs.
Bibliographic Information
- Other Title
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- Partial Hydrolysis of Soyasaponin 1 and the Hepatoprotective Effects of the Hydrolytic Products.Study of the Structure-Hepatoprotective Relationship of Soyasapogenol B Analogs
- Partial Hydrolysis of Soyasaponin 1 and
- Partial hydrolysis of soyasaponin I and the hepatoprotective effects of the hydrolytic products. Study of the structure-hepatoprotective relationship of soyasapogenol B analogs
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Description
As a part of our studies of hepatoprotective drugs, we prepared some soyasapogenol B analogs from soyasaponin I. We examined the hepatoprotective effects of these analogs, using immunologically-induced liver injury, in primary cultured rat hepatocytes. Soyasaponin III and soyasapogenol B monoglucuronide were more effective than soyasaponin I. Both compounds were significantly effective even at 30μM. The action of soyasapogenol B was almost equal to that of soyasaponin I, although glucuronic acid did not show any activity even at the highest dose (500μM). When the two compounds were mixed, the hepatoprotective action did not change, compared with soyasapogenol B. Therefore, we concluded that the linkage between glucuronic acid and soyasapogenol B could enhance the hepatoprotective activity.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 46 (2), 359-361, 1998
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679140443904
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- NII Article ID
- 110003616872
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DyaK1cXhtlCitro%3D
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- ISSN
- 13475223
- 00092363
- http://id.crossref.org/issn/00092363
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- NDL BIB ID
- 4406166
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- PubMed
- 9501471
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed