Synthesis and in Vitro Antiprotozoal Activity of Thiophene Ring-Containing Quinones.

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Abstract

A series of quinones (3a-i, 4-9, 11) and aromatic compounds (2a, 2b, 2g) containing the thiophene ring were tested in vitro against the trypomastigote form of Trypanosoma cruzi and the promastigote forms of Leishmania. The quinones 3a-i, 4, 5a, b, 6 and 9 having the thiophene ring fused to a quinone nucleus were the most active members of the series. The electron affinities of the benzo[b]thiophene-4, 7-quinones 3, evaluated by their LUMO energies and halfwave potentials, are reported.

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