Studies on New Platelet Aggregation Inhibitors 1. Synthesis of 7-Nitro-3,4-dihydroquinoline-2(1H)-one Derivatives.
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- IYOBE Akira
- Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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- UCHIDA Masahiko
- Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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- KAMATA Kouji
- Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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- HOTEI Yukihiko
- Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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- KUSAMA Hiroshi
- Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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- HARADA Hiromu
- Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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Abstract
A series of 6-cyclic aliphatic amino-7-nitro-3, 4-dihydroquinoline-2(1H)-ones were prepared and tested for platelet aggregation inhibitory effect, cardiotonic activity and chronotropic activity. These compounds appeared to show selective inhibitory activity against platelet aggregation. Among them, 6-(4-ethoxycarbonylpiperidino)-7-nitro-3, 4-dihydroquinoline-2(1H)-one (22f) showed the most potent inhibitory activity and high selectivity. A divergent synthetic route to 6-cyclic aliphatic amino-7-nitro-3, 4-dihydroquinoline-2(1H)-one derivatives has also been investigated.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 49 (7), 822-829, 2001
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679140536704
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- NII Article ID
- 110003616000
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXkvVartLw%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 5820257
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- PubMed
- 11456086
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed