Synthesis and Cytotoxic Activity of Acronycine Derivatives Modified at the Pyran Ring.

DOI Web Site Web Site PubMed 被引用文献2件 参考文献16件

書誌事項

タイトル別名
  • Synthesis and Cytotoxic Activity of Acr

この論文をさがす

説明

Nitration of acronycine (1) and 6-demethoxyacronycine (3) afforded 2-nitroacronycine (2) and 2-nitro-6-demethoxyacronycine (4), respectively. Reduction of 2-nitroacronycine yielded, depending on the conditions, 2-nitro-1, 2-dihydroacronycine (5), 2-oxo-1, 2-dihydroacronycine oxime (7) or 2-amino-1, 2-dihydroacronycine (6). This latter was readily converted into 2-dimethylamino-1, 2-dihydroacronycine (8), 2-acetylamino-1, 2-dihydro-acronycine (9) and 2-benzoylamino-1, 2-dihydroacronycine (10).The cytotoxicity of these compounds was evaluated against L1210 leukemia cells. Compounds 2 and 7 were 300- and 10-fold more potent than acronycine in inhibiting L1210 cell proliferation, respectively. Compound 2 was devoid of antitumor activity against P388 leukemia and C38 colon adenocarcinoma.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (16)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ