Dissolution Tests for Self-Setting Calcium Phosphate Cement-Containing Nifedipine.

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  • Suzuki Toyofumi
    Department of Pharmaceutics, College of Pharmacy, Nihon University
  • Arai Kifumi
    Department of Pharmaceutics, College of Pharmacy, Nihon University
  • Goto Hiroko
    Department of Pharmaceutics, College of Pharmacy, Nihon University
  • Hanano Manabu
    Department of Pharmaceutics, College of Pharmacy, Nihon University
  • Watanabe Jun
    Department of Pharmaceutics, College of Pharmacy, Nihon University
  • Tomono Kazuo
    Department of Pharmaceutics, College of Pharmacy, Nihon University

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Description

Nifedipine-containing calcium phosphate cement (CPC) was prepared, and nifedipine (NF) release from this preparation was evaluated by the shaking method (SK), Japanese Pharmacopoeia XIV (JPXIV) paddle method (PD), and JPXIV flow-through cell method (FT). The release of NF from the CPC preparation continued for 7 d or longer by all these methods. This suggests that the release of NF can be controlled by preparing NF-containing CPC. The release pattern of NF from CPC in these tests was found to follow the Higuchi equation. However, the Higuchi constant differed among the three dissolution tests, probably because the apparent tortuosity of capillary system (τ) varied.

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