Role of the Hydrophobic Moiety of Tumor Promoters. Synthesis and Activity of Benzolactams with Alkyl Substituents at Various Positions.

DOI Web Site Web Site 1 Citations 14 References

Bibliographic Information

Other Title
  • Role of the Hydrophobic Moiety of Tumor

Search this article

Abstract

We synthesized benzolactams with hydrophobic substituents at various positions as analogs of (-)-benzolactam-V8-310 ((-)-BL-V8-310, 1) which reproduces the active conformation and biological activity of teleocidins. Structure-activity data indicate that the existence of a hydrophobic region between C-2 and C-9, and the steric factor at C-8 play critical roles in the appearance of biological activities.

Journal

Citations (1)*help

See more

References(14)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top