Synthesis and in Vitro Cytotoxic Evaluation of New Derivatives of Pyrido[1,2-a]benzimidazolic Ring System: The Pyrido[1',2':1,2]imidazo[4,5-h]quinazolines.
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- DUPUY Marianne
- Laboratoire de Chimie organique Pharmaceutique Laboratoire d’oncopharmacologie, Centre Régional de Lutte contre le Cancer
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- PINGUET Frederic
- Laboratoire d’oncopharmacologie, Centre Régional de Lutte contre le Cancer
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- CHAVIGNON Olivier
- Laboratoire de Chimie Organique Pharmaceutique, UFR de Pharmacie
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- CHEZAL Jean-Michel
- Laboratoire de Chimie Organique Pharmaceutique, UFR de Pharmacie
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- TEULADE Jean-Claude
- Laboratoire de Chimie Organique Pharmaceutique, UFR de Pharmacie
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- CHAPAT Jean-Pierre
- Laboratoire de Chimie organique Pharmaceutique
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- BLACHE Yves
- Laboratoire de Chimie organique Pharmaceutique
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Abstract
Access to the original series of pyrido[1',2':1,2]imidazo[4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some “N-C-N” bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytotoxic activities against HL60 and A2780 cells. All compounds exhibited cytotoxic activitise on resistant cell lines (MDR+; HL60R and A2780R) with no resistance phenomena.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 49 (9), 1061-1065, 2001
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679141166848
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- NII Article ID
- 110003616049
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXmsFyksLc%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 5892529
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- PubMed
- 11558586
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed