A stereoselective synthesis of a stable prostacyclin analogue ; dl-3-Oxa-9(O)-methano-.DELTA.6(9.ALPHA.)-prostaglandin I1.
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- KOJIMA KOICHI
- Chemical Research Laboratories, Sankyo Co., Ltd.
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- KOYAMA KAZUO
- Chemical Research Laboratories, Sankyo Co., Ltd.
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- AMEMIYA SHIGEO
- Chemical Research Laboratories, Sankyo Co., Ltd.
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- SAITO SHINICHI
- Chemical Research Laboratories, Sankyo Co., Ltd.
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説明
A prostacyclin analogue, dl-3-oxa-9 (Ο)-methano-Δ6 (9α) -prostaglandin I1 (1a), has been synthesized. The key step for this synthesis is a new, one-step conversion reaction of the (hydroxymethyl) cyclopropylketone group in 8 and 21 to the γ, δ-unsaturated ketone 9 and 22, respectively, with iodotrimethylsilane.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 35 (3), 948-956, 1987
公益社団法人 日本薬学会