Pyridonecarboxylic acids as antibacterial gaents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives.
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- MIYAMOTO TERUYUKI
- Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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- MATSUMOTO JUN-ICHI
- Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
書誌事項
- 公開日
- 1987
- 資源種別
- journal article
- DOI
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- 10.1248/cpb.35.2280
- 公開者
- 公益社団法人 日本薬学会
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説明
An alternative synthesis of enoxacin, a 1, 8-naphthyridine antibacterial agent, was developed. The present method involves 1, 8-naphthyridine ring construction by the Dieckmann type cyclization of ethyl 5-fluoronicotinate having a 2-ethoxycarbonylethylamino moiety at C-2. This nicotinate was prepared in 7 steps from ethyl fluoroacetate via ethyl 2, 6-dichloro-5-fluoronicotinate.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 35 (6), 2280-2285, 1987
公益社団法人 日本薬学会