Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes

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  • Nishide Midori
    Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
  • Yoshikawa Yutaka
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
  • Yoshikawa Eriko U.
    Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
  • Matsumoto Kinuyo
    Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
  • Sakurai Hiromu
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
  • KAJIWARA Naemi M.
    Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University

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  • Insulinomimetic Zn(2) complexes as evaluated by both glucose-uptake activity and inhibition of free fatty acids release in isolated rat adipocytes

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We prepared 4 new Zn(II) complexes with Zn(O4), Zn(N2O2), and Zn(S2O2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)2), bis(α-furonic acidato)zinc (Zn(fa)2), bis(thiophene-2-carboxylato)zinc (Zn(tc)2), and bis(thiophene-2-acetato)zinc (Zn(ta)2) complexes were found to be higher than that of zinc sulfate (ZnSO4). Zn(ta)2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity.

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