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The use of N-hydroxy-5-norbornene-2,3-dicarboximide acitive esters in peptide synthesis.
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Description
N-Hydroxy-5-norbornene-2, 3-dicarboximide (HONB) was found to be an excellent reagent to be used in couple with N, N'-dicyclohexylcarbodiimide (DCC) for the peptide synthesis. Various racemization tests by the use of this reagent were conducted to see the degree of racemization during the peptide synthesis. The newly employed reagent (HONB) decreases racemization, prohibits formation of N-acylurea and affords peptides in excellent yields and a high state of purity. To evaluate this new reagent, luteinizing hormone releasing hormone (LH-RH) was prepared by the new active ester method.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 22 (8), 1857-1863, 1974
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679145025664
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- NII Article ID
- 110003633373
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DyaE2cXlt1Squrc%3D
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- ISSN
- 13475223
- 00092363
- http://id.crossref.org/issn/00092363
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- PubMed
- 4609627
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed