Larvicidal, Antimycobacterial and Antifungal Compounds from the Bark of the Peruvian Plant Swartzia polyphylla DC

DOI Web Site 1 Citations 27 References
  • Rojas Rosario
    Departamento de Ciencias Farmacéuticas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia
  • Bustamante Betty
    Instituto de Medicina Tropical “Alexander von Humboldt”, Universidad Peruana Cayetano Heredia
  • Ventosilla Palmira
    Instituto de Medicina Tropical “Alexander von Humboldt”, Universidad Peruana Cayetano Heredia
  • Fernádez Irma
    Departamento de Ciencias Farmacéuticas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia
  • Caviedes Luz
    Departamento de Microbiología, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia
  • Gilman Robert Henry
    Departamento de Microbiología, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia Department of International Health, Johns Hopkins School of Public Health
  • Lock Olga
    Departamento de Química, Pontificia Universidad Católica del Perú
  • Hammond Gerald Bruce
    Department of Chemistry, University of Louisville

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Description

The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.

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