Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii
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- Jang JunPil
- Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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- Na MinKyun
- Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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- Thuong Phuong Thien
- College of Pharmacy, Chosun University
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- Njamen Dieudonné
- Faculty of Science, University of Yaounde I
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- Mbafor Joseph Tanyi
- Faculty of Science, University of Yaounde I
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- Fomum Zacharias Tanee
- Faculty of Science, University of Yaounde I
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- Woo Eun-Rhan
- College of Pharmacy, Chosun University
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- Oh Won Keun
- College of Pharmacy, Chosun University
書誌事項
- 公開日
- 2008
- DOI
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- 10.1248/cpb.56.85
- 公開者
- 公益社団法人 日本薬学会
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説明
Phytochemical study on an EtOAc-soluble extract of the root bark of Erythrina mildbraedii resulted in the isolation of six prenylated flavonoids 1—6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4′-O-methyl ether (1), 2′,7-dihydroxy-4′-methoxy-5′-(3-methylbut-2-enyl)isoflavone (2), and (3R)-2′,7-dihydroxy-3′-(3-methylbut-2-enyl)-2‴,2‴-dimethylpyrano[5‴,6‴ :4′,5′]isoflavan (3), along with three known compounds erythrinin B (4), abyssinin II (5), and parvisoflavone B (6). All the isolates, except for compound 4, inhibited PTP1B activity in vitro with IC50 values ranging from 5.3 to 42.6 μM. This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 56 (1), 85-88, 2008
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679145260928
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- NII論文ID
- 110006531697
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 9313480
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDLサーチ
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