A study of the calcium complex of a glucosylceramide, soya-cerebroside 2
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- Kurosu Michio
- Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University
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- Katayama Seiji
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Shibuya Hirotaka
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Kitagawa Isao
- Graduate School of Pharmaceutical Sciences, Osaka University
書誌事項
- タイトル別名
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- A Study of the Calcium Complex of a Glucosylceramide, Soya-cerebroside II
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説明
In order to study calcium ion complex of soya-cerebroside II (1), an ionophoretic glucosylceramide isolated from soybean, C8-cerebroside (3) and 3,3″,6″-trideoxy-C8-cerebroside (4) are designed and synthesized. On the basis of extensive 1H-NMR studies in the presence of Ca2+ and a continuous variation method via 1H-NMR, soya-cerebroside II is suggested to form a calcium complex with 1/Ca2+ ratio of 1 : 1. Soya-cerebroside II serves as a tridentate chelating ligand for Ca2+; the amide carbonyl, C2′-hydroxy, and C2″-hydroxy oxygens are responsible for the Ca2+ binding. Soya-cerebroside II is structurally analogous to a neural glucosylceramide. Thus, the accumulated neural glucosylceramide inside of endoplasmic reticulum (ER) membrane may serve as an endogenous Ca2+-binding and -transport molecule (ionophore) that result in mobilization of Ca2+ from intracellular calcium stores.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 55 (12), 1758-1761, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679145344384
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- NII論文ID
- 110006532123
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 9274154
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- PubMed
- 18057755
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- 本文言語コード
- en
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