A New Phenanthrene Glycoside and Other Constituents from Dioscorea opposita

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  • Sautour Marc
    Laboratoire de Pharmacognosie, Unité UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne
  • Mitaine-Offer Anne-Claire
    Laboratoire de Pharmacognosie, Unité UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne
  • Miyamoto Tomofumi
    Graduate School of Pharmaceutical Sciences, Kyushu University
  • Wagner Hildebert
    Center of Pharmaresearch, Pharmaceutical Biology, University of Munich
  • Lacaille-Dubois Marie-Aleth
    Laboratoire de Pharmacognosie, Unité UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne

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  • New Phenanthrene Glycoside and Other Constituents from Dioscorea opposita

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Phytochemical investigation of the rhizome of Dioscorea opposita has led to the isolation of a new phenanthrene glycoside, 3,4,6-trihydroxyphenanthrene-3-O-β-D-glucopyranoside (1), and five known compounds, soyacerebroside I (2), adenosine (3), β-sitosterol (4), palmitic acid (5) and palmitoyloleoylphosphatidylcholine (6). Their structures were determined by spectroscopic methods, including 1D- and 2D-NMR. Compounds 1—6 exhibited no antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis.

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