Synthesis, Anticancer and Antibacterial Activity of Some Novel Mononuclear Ru(II) Complexes
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- Mazumder Upal Kanti
- Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University
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- Gupta Malaya
- Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University
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- Karki Subhas Somalingappa
- Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University
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- Bhattacharya Shiladitya
- Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University
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- Rathinasamy Suresh
- Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University
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- Thangavel Sivakumar
- Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University
書誌事項
- タイトル別名
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- Synthesis Anticancer and Antibacterial Activity of Some Novel Mononuclear Ru 2 Complexes
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抄録
In search of potential anticancer drug candidates in ruthenium complexes, a series of mononuclear ruthenium complexes of the type [Ru(phen)2(nmit)]Cl2 (Ru1), [Ru(bpy)2(nmit)]Cl2 (Ru2), [Ru(phen)2(icpl)]Cl2 (Ru3), Ru(bpy)2(icpl)]Cl2 (Ru4) (phen=1,10-phenanthroline; bpy=2,2′-bipyridine; nmit=N-methyl-isatin-3-thiosemicarbazone, icpl=isatin-3-(4-Cl-phenyl)thiosemicarbazone) and [Ru(phen)2(aze)]Cl2 (Ru5), [Ru(bpy)2(aze)]Cl2 (Ru6) (aze=acetazolamide) and [Ru(phen)2(R-tsc)](ClO4)2 (R=methyl (Ru7), ethyl (Ru8), cyclohexyl (Ru9), 4-Cl-phenyl (10), 4-Br-phenyl (Ru11), and 4-EtO-phenyl (Ru12), tsc=thiosemicarbazone) were prepared and characterized by elemental analysis, FTIR, 1H-NMR and FAB-MS. Effect of these complexes on the growth of a transplantable murine tumor cell line (Ehrlich Ascites Carcinoma) and their antibacterial activity were studied. In cancer study the effect of hematological profile of the tumor hosts have also been studied. In the cancer study, the complexes Ru1—Ru4, Ru10 and Ru11 have remarkably decreased the tumor volume and viable ascitic cell count as indicated by trypan blue dye exclusion test (p<0.05). Treatment with the ruthenium complexes prolonged the lifespan of Ehrlich Ascites Carcinoma (EAC) bearing mice. Tumor inhibition by the ruthenium chelates was followed by improvements in hemoglobin, RBC and WBC values. All the complexes showed antibacterial activity, except Ru5 and Ru6. Thus, the results suggest that these ruthenium complexes have significant antitumor property and antibacterial activity. The results also reflect that the drug does not adversely affect the hematological profiles as compared to that of cisplatin on the host.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 52 (2), 178-185, 2004
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679145467776
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- NII論文ID
- 110003615530
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 6826722
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- PubMed
- 14758001
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可