Anchoring of Ulex Europaeus Agglutinin to Chitosan Nanoparticles-in-Microparticles and Their in Vitro Binding Activity to Bovine Submaxillary Gland Mucin
-
- Li Feng-Qian
- Shanghai Eighth People's Hospital
-
- Fei Yi-Bo
- Changhai Hospital, Second Military Medical University
-
- Chen Xu
- Shanghai Eighth People's Hospital
-
- Qin Xian-Ju
- Shanghai Eighth People's Hospital
-
- Liu Ji-Yong
- Changhai Hospital, Second Military Medical University
-
- Zhu Quan-Gang
- Changhai Hospital, Second Military Medical University
-
- Hu Jin-Hong
- Changhai Hospital, Second Military Medical University
この論文をさがす
抄録
Focused on the natural biodegradable material of chitosan (CS), this investigation concerned its spray-dried nanoparticles-in-microparticles (NiMPs) modified with ulex europaeus agglutinin (UEA). Chitosan nanoparticles were obtained by ionotropic gelation process with pentasodium tripolyphosphate as gelatinizer. Then UEA lectin was bound onto the CS nanoparticles activated by glutaraldehyde. The conjugated spherical UEA-CS-NiMPs, prepared by spray drying method, exhibited 12—85% coupling efficiency of UEA depending upon the amount of activator glutaraldehyde. And the UEA-grafted particles showed additional higher binding tendency with bovine submaxillary gland mucin as compared to the plain chitosan microparticles. Furthermore, the activity and intrinsic fucose-specificity of UEA were still maintained after the covalent modification. It is thus evident that the UEA anchored CS-NiMPs might be used as a potential drug delivery system targeted to the specific regions of gastrointestinal tract.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 57 (10), 1045-1049, 2009
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679145529216
-
- NII論文ID
- 130000124774
-
- NII書誌ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 10376094
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可