Development of Positron-Emission Tomography/Single-Photon Emission Computed Tomography Imaging Probes for in Vivo Detection of .BETA.-Amyloid Plaques in Alzheimer's Brains
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- Ono Masahiro
- Department of Patho-Functional Bioanalyses, Graduate School of Pharmaceutical Sciences, Kyoto University
Bibliographic Information
- Other Title
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- Development of positron-emission tomography/single-photon emission computed tomography imaging probes for in vivo detection of β-amyloid plaques in Alzheimer's brains
- Development of positron emission tomography single photon emission computed tomography imaging probes for in vivo detection of v amyloid plaques in Alzheimer s brains
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Description
Currently, the development of radiotracers for in vivo imaging of β-amyloid plaques in Alzheimer's disease (AD) brains is an important, active area of molecular imaging. Postmortem brains of AD patients reveal neuropathologic features: the presence of β-amyloid plaques and neurofibrillary tangles, which contain β-amyloid peptides and highly phosphorylated tau proteins. Increases in the concentration of β-amyloid in the course of the disease lead to changes in AD brains. Thus, when used in combination with positron-emission tomography/single-photon emission computed tomography (PET/SPECT), β-amyloid imaging agents could serve as surrogate markers for the early diagnosis and neuropathogenetic studies of AD. Furthermore, quantitative evaluation of β-amyloid plaques in the brain could facilitate the evaluation of the efficacy of antiamyloid therapies that are currently being investigated. This paper reviews our research on the development of PET/SPECT imaging agents for in vivo detection of β-amyloid plaques in Alzheimer's brains.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 57 (10), 1029-1039, 2009
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679145534208
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- NII Article ID
- 130000124772
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 10376075
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed