Radical-Scavenging Activities of New Megastigmane Glucosides from Macaranga tanarius (L.) MUELL.-ARG.

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  • Matsunami Katsuyoshi
    Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University
  • Takamori Ichiko
    Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University
  • Shinzato Takakazu
    Subtropical Field Science Center, Faculty of Agriculture, University of the Ryukyus
  • Aramoto Mitsunori
    Iriomote Station, Tropical Biosphere Research Center, University of the Ryukyus
  • Kondo Kazunari
    Division of Foods, National Institute of Health Sciences
  • Otsuka Hideaki
    Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University
  • Takeda Yoshio
    Faculty of Integrated Arts and Sciences, The University of Tokushima

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  • Radical-Scavenging Activities of New Megastigmame Glucosides from Macaranga tanarius (L.) MULL.-ARG
  • Radical-scavenging activities of new megastimane glucosides from Macaranga tanarius (L.) MULL-ARG

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Four new megastigmane glucosides, named macarangiosides A—D (2—5), together with mallophenol B, lauroside E, methyl brevifolin carboxylate, and hyperin and isoquercitrin as a mixture were isolated from the leaves of Macaranga tanarius (L.) MÜLL.-ARG. (Euphorbiaceae). Their structures were elucidated by spectroscopic and chemical analyses. Macarangioside A—C (2—4) and mallophenol B were galloylated on glucose moiety and possessed the potent 2,2-diphenyl-picrylhydrazyl (DPPH) radical-scavenging activity.

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