New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum

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  • Mori Jun
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University Department of Pharmaceutical Research, Lead Chemical Co., Ltd.
  • Iwashima Makoto
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Wakasugi Hiroko
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Saito Haruo
    Department of Pharmaceutical Research, Lead Chemical Co., Ltd.
  • Matsunaga Takayuki
    Toyama Prefectural Institute for Pharmaceutical Research
  • Ogasawara Masaru
    Toyama Prefectural Institute for Pharmaceutical Research
  • Takahashi Satoshi
    Toyama Prefectural Institute for Pharmaceutical Research
  • Suzuki Hideyo
    Toyama Prefectural Institute for Pharmaceutical Research
  • Hayashi Toshimitsu
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

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Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.

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