New Sphingolipids and a Sterol from a Lobophytum Species of the Indian Ocean
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- Muralidhar Pendyala
- Department of Pharmaceutical Sciences, Andhra University
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- Kumar Muthyala Muralikrishna
- Department of Pharmaceutical Sciences, Andhra University
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- Krishna Nallamothu
- Department of Pharmaceutical Sciences, Andhra University
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- Rao Chaganty Bheemasankara
- Department of Organic Chemistry, Andhra University
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- Rao Desaraju Venkata
- Department of Pharmaceutical Sciences, Andhra University
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Abstract
Chemical investigation of a soft coral species of the genus Lobophytum has resulted in the isolation of three new sphingolipids—(2S,3S,4R)-2-nonadecanoylamino-octadecane-1,3,4-triol (1), (2S,3R,4E,8E)-[(2′R)-2′-hydroxyheptadecanoylamino]-4,8-octadecadiene-1,3-diol (2), 1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(2′R)-2′-hydroxynonadecanoylamino]-9-methyl-4,8-octadecadiene-1,3-diol (3) and a sterol—(24S)-ergost-5-en-3β,7β-diol (4) along with the known sphingolipid—(2S,3R,4E,8E)-2-hexadecanoylamino-4,8-octadecadien-1,3-diol (5) which showed cytotoxicity against human peripheral blood mononuclear cells (PBMC).
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 53 (2), 168-171, 2005
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679145781376
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- NII Article ID
- 10016651992
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 7233560
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- PubMed
- 15684514
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed