Thalidomide Analogs from Diamines: Synthesis and Evaluation as Inhibitors of TNF-.ALPHA. Production

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  • Thalidomide Analogs from Diamines: Synthesis and Evaluation as Inhibitors of TNF-α Production
  • Thalidomide Analogs from Diamines Synthesis and Evaluation as Inhibitors of TNF アルファ Production

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Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83—94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-α production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.

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