Chemical Constituents from the Leaves of Manglietia phuthoensis and Their Effects on Osteoblastic MC3T3-E1 Cells

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  • Kiem Phan Van
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology
  • Tri Mai Dinh
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology
  • Tuong Le Vo Dinh
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology
  • Tung Nguyen Huu
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology College of Pharmacy, Chungnam National University
  • Hanh Nguyen Ngoc
    Institute of Chemical Technology
  • Quang Tran Hong
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology
  • Cuong Nguyen Xuan
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology
  • Minh Chau Van
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology
  • Choi Eun-Mi
    College of Pharmacy, Chungnam National University
  • Kim Young Ho
    College of Pharmacy, Chungnam National University

書誌事項

公開日
2008
DOI
  • 10.1248/cpb.56.1270
公開者
公益社団法人 日本薬学会

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説明

Two new phenyl glycosides, mangliesides A and B (1, 2), a new ionol glycoside, manglieside C (3), two new lignan glycosides, mangliesides D and E (4, 5), were isolated from the leaves of Manglietia phuthoensis, along with two known lignans, 3-methoxymagnolol (6) and obovatol (7). Their structures were established by means of 1D and 2D NMR, electrospray ionization (ESI)-MS and HR-ESI-MS experiments. Among them, compounds 2 and 5 significantly (p<0.05) increased the growth and differentiation of osteoblastic MC3T3-E1 cells in vitro.

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