Synthesis of Purine Nucleosides Using Iodine as Catalyst

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Iodine has been found to be an excellent catalyst for the synthesis of nucleosides, i.e., the reaction of 1-O-acetyl-2, 3, 5-tri-O-benzoyl-β-D-ribofuranose with various purines in the presence of iodine resulted in the formation of corresponding 9-β-D-ribonucleosides, and/or their isomers in good yields.

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